ZK168281, a 25-carboxylic ester derivative of 1α,25(OH)2D3, is a novel, potent and pure VDR antagonist with a Kd value of 0.1 nM. ZK168281 is an effective inhibitor of the coactivator (CoA) interaction of its receptor.

References: [1]. Lempiainen H, et al. Antagonist- and inverse agonist-driven interactions of the vitamin D receptor and the constitutive androstane receptor with corepressor protein. Mol Endocrinol. 2005 Sep;19(9):2258-72.

纯度：≥98%

CAS：186371-96-0