6RK73 is a covalent irreversible and specific UCHL1 inhibitor with an IC50 of 0.23 μM. 6RK73 shows almost no inhibition of UCHL3 (IC50=236 μM). 6RK73 specifically inhibit UCHL1 activity in breast cancer. References: [1]. Liu S, et al. Deubiquitinase activity profiling identifies UCHL1 as a candidate oncoprotein that promotes TGFβ-induced breast cancer metastasis. Clin Cancer Res. 2019 Dec 19. pii: clincanres.1373.2019.

纯度：≥98%

CAS：1895050-66-4