APTO-253 HCl (LOR-253; LT-253) is a novel and potent MTF-1 inhibitor with anti-tumor activity. It acts in cancer cells via induction of the gene that expresses the Krüppel-like factor 4 (KLF4) master transcription factor, leading to cell cycle inhibition and programmed cell death. It also inhibits c-Myc expression, stabilizes G-quadruplex DNA, and induces cell cycle arrest and apoptosis in acute myeloid leukemia cells.

纯度：≥98%

CAS：1691221-67-6