[登录] [免费注册]
试剂仪器网
发布求购
位置：首页 > 产品库 > ERAP1-IN-1
立即咨询
咨询类型：
     
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
 
ERAP1-IN-1
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
ERAP1-IN-1图片
CAS NO:865273-97-8
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
ERAP1-in-1是内质网氨基肽酶1(ERAP1)抑制剂，能竞争性地抑制ERAP1对代表性生物底物九聚物肽的作用。
Cas No.865273-97-8
Canonical SMILESO=C(O)C1=CC=C(OC)C(S(=O)(NC2=CC(C(F)(F)F)=CC=C2N3CCCCC3)=O)=C1
分子式C20H21F3N2O5S
分子量458.45
溶解度DMSO: 250 mg/mL (545.32 mM)
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

ERAP1-IN-1 is an endoplasmic reticulum aminopeptidase 1 (ERAP1) inhibitor. ERAP1-IN-1 competitively inhibits ERAP1 activity towards a nonamer peptide representative of physiological substrates[1].

ERAP1-IN-1 allosterically activates ERAP1's hydrolysis of fluorogenic and chromogenic amino acid substratesv[1].ERAP1-IN-1 (50 µM) exhibits specific inhibition of ERAP1 in the cellular context[1].

[1]. Maben Z, et al. Discovery of Selective Inhibitors of Endoplasmic Reticulum Aminopeptidase 1. J Med Chem. 2019 Dec 30.