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Fmoc-3VVD-OH
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Fmoc-3VVD-OH图片
CAS NO:863971-44-2
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
Fmoc-3VVD-OH是一种可降解(non-cleavable)的ADC连接桥，用于抗体药物结合物(ADCs)的合成。
Cas No.863971-44-2
Canonical SMILESCN([C@H]([C@H](OC)CC(O)=O)[C@@H](C)CC)C([C@H](C(C)C)NC([C@H](C(C)C)N(C(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O)C)=O)=O
分子式C36H51N3O7
分子量637.81
溶解度DMSO: ≥ 37 mg/mL (58.01 mM); Water:< 0.1 mg/mL (insoluble)
储存条件4℃, stored under nitroge
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Fmoc-3VVD-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1].

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

[1]. Michinori Akaiwa, et al. Synthesis and Evaluation of Linear and Macrocyclic Dolastatin 10 Analogues Containing Pyrrolidine Ring Modifications. ACS Omega. 2018 May 31;3(5):5212-5221.