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GRP-60367 hydrochloride
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
GRP-60367 hydrochloride图片
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议
10mg电议

产品介绍
GRP-60367hydrochloride是种首创的小分子狂犬病病毒(RABV)进入抑制剂，对某些RABV株具有纳摩尔作用效果。GRP-60367hydrochloride特异性靶向RABVG蛋白。
Canonical SMILESCC1=C(OCCNC2CCN(C(C3=CC=NC=C3)=O)CC2)C=C(C)C=C1.[H]Cl
分子式C21H28ClN3O2
分子量389.92
溶解度DMSO: 250 mg/mL (641.16 mM)
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

GRP-60367 hydrochloride is a first-in-class small-molecule rabies virus (RABV) entry inhibitor with nanomolar potency against some RABV strains. GRP-60367 hydrochloride specifically targets the RABV G protein[1].

GRP-60367 (0.1 nM-1000 μM) confirms specific and potent anti-RABV activity of the scaffold, returning in dose-response assays EC50s ranging from 2 to 52 nM on different host cell lines[1]. Cell Viability Assay[1] Cell Line: BEAS-2B, 293T, or Hep-2 cell lines

[1]. Venice Du Pont, et al. Identification and Characterization of a Small-Molecule Rabies Virus Entry Inhibitor. J Virol. 2020 Jun 16;94(13):e00321-20.