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M77976
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
M77976图片
CAS NO:394237-61-7
包装与价格：
包装价格(元)
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
M77976 是一种特异性的，ATP 竞争性的丙酮酸脱氢酶激酶 PDK4 抑制剂，其作用的 IC50 值为 648 μM。M77976 有用于肥胖症和糖尿病研究的潜力。
Cas No.394237-61-7
Canonical SMILESCOC1=CC=C(C=C1)C2=C(NN=C2C3=CC=C(C=C3O)O)C
分子式C17H16N2O3
分子量296.32
溶解度DMSO: 250 mg/mL (843.68 mM)
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

M77976 is a specific ATP-competitive inhibitor of PDK4 (pyruvate dehydrogenase kinase isoforms 4), with an IC50 of 648 μM. M77976 is potential for the research of obesity and diabetes[1].

M77976 binds to the ATP-binding pocket of PDK4 and causes local conformational changes with complete disordering of the ATP lid[1].M77976 makes hydrophobic interactions with the side chains of Asn258, Ala262, Val298, Leu306 and Thr358 of PDK4[1].

[1]. Kukimoto-Niino M, et al. Inhibitor-bound structures of human pyruvate dehydrogenase kinase 4. Acta Crystallogr D Biol Crystallogr. 2011 Sep;67(Pt 9):763-73.