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Pomalidomide-PEG4-azide
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Pomalidomide-PEG4-azide图片
CAS NO:2271036-47-4
包装与价格：
包装价格(元)
100mg电议
250mg电议

产品介绍
Pomalidomide-PEG4-azide是一种PROTAClinker，属于PEG类。可用于合成PROTAC分子。
Cas No.2271036-47-4
Canonical SMILESO=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=CC=C3NCCOCCOCCOCCOCCN=[N+]=[N-])=O
分子式C23H30N6O8
分子量518.52
储存条件-20°C, protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Pomalidomide-PEG4-azide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562