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Dipraglurant
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Dipraglurant图片
CAS NO:872363-17-2
包装与价格：
包装价格(元)
5mg电议
10mg电议
25mg电议

产品介绍
Dipraglurant (ADX48621) 是一种有效的、选择性的、具有口服活性和脑渗透性的 mGluR5 负变构调节剂 (NAM)，IC50 为 21 nM。
Cas No.872363-17-2
别名6-氟-2-[4-(吡啶-2-基)-3-丁炔基]咪唑并[1,2-A]吡啶,ADX 48621;ADX48621;ADX-48621
化学名6-fluoro-2-(4-pyridin-2-ylbut-3-ynyl)imidazo[1,2-a]pyridine
Canonical SMILESC1=CC=NC(=C1)C#CCCC2=CN3C=C(C=CC3=N2)F
分子式C16H12FN3
分子量265.29
溶解度Soluble in DMSO
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Dipraglurant (ADX 48621) is a mGluR5 antagonists with IC50 of 0.021 μM. IC50 Value: 0.021 μM [1]Target: mGluRDipraglurant (ADX-48621) from Addex Therapeutics showed in vivo activity in different anxiety models in rat50 and is currently in phase II for the treatment of dyskinesia in Parkinson's disease.

References:
[1]. The Synthesis and Use of Certain Pyridine Derivatives as Modulators of the G-protein Coupled Receptors mGlu5 and P2Y12