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Iodophenpropit dihydrobromide
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Iodophenpropit dihydrobromide图片
CAS NO:145196-87-8
包装与价格：
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Iodophenpropit dihydrobromide 是一种有效的选择性组胺H3受体 (histamine H3 receptor) 拮抗剂。[125I] Iodophenpropit 结合 H3 受体具有选择性，可饱和，易于可逆，及高亲和力 (KD为 0.32 nM)。
生物活性

Iodophenpropit dihydrobromide is a potent and selectivehistamine H3 receptorantagonist. The binding of [125I]Iodophenpropit is selective, saturable, readily reversible, and of high affinity (KD0.32 nM)[1].

IC50& Target[1]

H3Receptor

0.32 nM (Kd)

体外研究
(In Vitro)

Iodophenpropit is a very potent H3 receptor antagonist and shows only a moderate affinity for the H1 and H2 receptor[2].
Iodophenpropit inhibit 5-hydroxytryptamine (5-HT) responses with an IC50of 1.57±0.3 μM[3].

体内研究
(In Vivo)

Iodophenpropit (1 μg/kg; through intramuscular; b.i.d.; for 10 days) shows significant enhancement of total anti- sheep red blood cells (SRBC)- immunoglobulins (Igs) in rabbits[4].

Animal Model:New Zealand adult healthy rabbits of either sex weighing 1.63±0.36 kg[4]
Dosage:1 μg/kg
Administration:Administered through intramuscular (i.m.); b.i.d.; for 10 days
Result:Could influence a detectable antibody response to SRBC.
分子量

576.13

Formula

C15H21Br2IN4S

CAS 号

145196-87-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.