Mesdopetam

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Mesdopetam

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

1403894-72-3

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品名称

IRL790

产品介绍

Mesdopetam (IRL790) 是一种多巴胺D3受体拮抗剂 (K_i=90 nM;IC₅₀=9.8 μM)，具有稳定精神运动的特性。Mesdopetam 用于研究帕金森病的运动和精神并发症。

生物活性

Mesdopetam (IRL790) is a dopamineD3 receptorantagonist (K_i=90 nM;IC₅₀=9.8 μM for human recombinant D3 receptor) with psychomotor stabilizing properties. Mesdopetam is used for the research of motor and psychiatric complications in Parkinson disease^[1]^[2].

IC₅₀& Target^[1]

D₃Receptor

体内研究
(In Vivo)

Mesdopetam (IRL790) (3.7, 11, 33, or 100 μmol/kg) dose-dependently inhibits the behavioral activation following pretreatment with D-amphetamine or MK-80^[1].

Animal Model:	Male Sprague-Dawley rats^[1]
Dosage:	3.7, 11, 33, or 100 μmol/kg (synthesized in-house as HCl salt, was dissolved in physiologic saline (0.9% w/v NaCl)
Administration:	s.c. was administered subcutaneously 4 min before the start of recording
Result:	Dose-dependently inhibited the behavioral activation following pretreatment with D-amphetamine or MK-801.

Clinical Trial

分子量

275.34

Formula

C₁₂H₁₈FNO₃S

CAS 号

1403894-72-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.