CYP1B1-IN-4 is a 2,4-diarylthiazole compound with selectivelyCYP1B1inhibition (IC₅₀=0.2 nM). CYP1B1-IN-4 has little cytotoxicity and high stability in both human and rat liver microsomes^[1].

CYP1B1-IN-4 (化合物15) (100 μM; 37 ℃; 0-60 min) 在人和大鼠肝微粒体中均具有体外稳定性，而在小鼠肝微粒体中稳定性较低^[1]。
CYP1B1-IN-4 (1 nM-10 μM) 抑制 CYP1A1, IC₅₀为 3.82 μM^[1]。
Cyp1b1-IN-4 (100 μM; 72 h) 对 HEK293 细胞无细胞毒性^[1]。

322.38

C₁₈H₁₄N₂O₂S

2685779-55-7

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