Dinactin, anantibioticionophore produced by Streptomyces species, as an effective small molecule targetingWnt/β-cateninsignaling pathway incancercells. Dinactin shows marked inhibition of HCT-116 cell growth with an IC₅₀of 1.1 μM. Dinactin shows anti-proliferative activity against thecancercells in apoptosis-independent manner. Dinactin is also an effective agent for the research of neuropathic pain^[1].

Dinactin (compound 1) shows antibacterial activity with MIC values of 1, 0.039, 0.019, 0.078, 0.078, 0.156, 0.156, 0.156, 0.156 μg/ml forM.tuberculosis(ATCC 25177),S. epidermidis(ATCC 12228),M. luteus(ATCC10240),S. aureus(ATCC 35923),E. faecalis(ATCC 51299),B. subtilis(ATCC 11774),E. coli(ATCC 10536),P. aeruginosa(ATCC 10145),K. pneumonia(ATCC BAA-2146) strain, respectively^[1].
Dinactin (0-100 μM) shows antitumor activity with IC₅₀values of 1.3, 1.1, 1.3, 1.5, 9.7, 80 μM for A549, HCT-116, T47D, MCF7, HepG2, HEK-293 cells, respectively^[1].
Dinactin (0.5, 1, 2 μM; 24 h) induces morphological changes in a concentration dependent manner in HCT-116 cells^[1].
inactin (0.5, 1, 2 μM; 24 h) effectively inhabits cell migration and invasion characteristics in HCT-116 cells^[1].

764.98

C₄₂H₆₈O₁₂

20261-85-2

二活菌素

Streptomyces aureus

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.