QD394 is areactive oxygen species(ROS) inducer that can induce lipid peroxidation, increase intracellular ROS accumulation, inhibitSTAT3phosphorylation, and induceferroptosis^[1].

QD394 (0-10 μM, 24 h) is cytotoxic with the IC₅₀values of 0.64, 0.34 and 0.9 μM for MIA PaCa-2, PANC-1 and BxPC-3 cell lines, respectively. And QD394 can inhibit the phosphorylation of STAT3 in cells and increase the phosphorylation of H2AX^[1].
QD394(1-10 μM, 4 h) mediates cell death by increasing cellular ROS levels and decreases GSH/GSSG ratio in MIA PaCa-2 cells; also induces iron-dependent and GPX4-mediated ferroptosis^[1].

349.39

C₁₉H₁₉N₅O₂

2132411-21-1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.