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LY5
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
LY5图片
CAS NO:1436382-03-4
包装与价格：
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
LY5 是STAT3的抑制剂，IC50值为 0.5 μM。LY5 诱导细胞凋亡并抑制 STAT3 磷酸化。LY5 具有体内抗肿瘤活性，可用于癌症的研究。
生物活性

LY5 is aSTAT3inhibitor with anIC50value of 0.5 μM. LY5 inducesapoptosisand inhibitsSTAT3phosphorylation. LY5 shows antitumor activity in vivo, it can be used for the research ofcancer[1].

IC50& Target

IC50: 0.5 μM (STAT3)[1]

体外研究
(In Vitro)

LY5 shows inhibition effects to U2OS, RH30 and RD2 cancer cells with IC50values of 0.52, 0.55 and 1.39 μM, respectively[1].
LY5 (0.25-1 μM; 16 h) induces apoptosis and inhibits STAT3 phosphorylation in human sarcoma cancer cells[1].
LY5 (0.25-1 μM; 5 h) inhibits STAT3 phosphorylation induced by IL-6[1].

Western Blot Analysis[1]

Cell Line:RH30 and EW8 cell lines
Concentration:0.25-1 μM
Incubation Time:16 hours
Result:Completely inhibited Tyr705 phosphorylation at 0.5 μM and dose-dependently decreased in formation of P-STAT3.
体内研究
(In Vivo)

LY5 (5 mg/kg; i.p. once daily for 21 days) inhibits breast tumor growth in vivo[1].

Animal Model:Nude mice with MDA-MB-231 cancer cells injection[1]
Dosage:5 mg/kg
Administration:Intraperitoneal injection; 5 mg/kg; once daily; for 21 days
Result:Suppressed tumor growth and significantly reduced the tumor sizes.
分子量

329.33

Formula

C15H11N3O4S

CAS 号

1436382-03-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.