Nemorosone 是Clusia rosea树脂的主要成分。Nemorosone 对癌细胞有抗增殖作用。Nemorosone 诱导 HT-29 和 LoVo 细胞凋亡 (apoptosis)。
| 生物活性 | Nemorosone is the main component of the floral resin ofClusia rosea. Nemorosone has an antiproliferative effect oncancercells. Nemorosone inducesapoptosisin HT-29 and LoVo cells[1][2]. |
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体外研究
(In Vitro) | Nemorosone (0-50 μM; 24-72 h) inhibits the proliferation of HT-29 and LoVo cells with IC50s of 25.7-27.1 μM, 22.8-64.3 μM, respectively[1].
Nemorosone (25.7 μM for HT-29; 22.8 μM for LoVo; 24, 48 hours) increases the percentage of G0/G1 phase cells[1].
Nemorosone (25.7 μM for HT-29; 22.8 μM for LoVo; 24, 48 hours) induces apoptosis in both cell lines[1].
Cell Proliferation Assay[1] | Cell Line: | HT-29 and LoVo cells | | Concentration: | 0-50 μM | | Incubation Time: | 24-72 h | | Result: | Inhibited the proliferation of HT-29 and LoVo cells with IC50s of 25.7-27.1 μM, 22.8-64.3 μM, respectively. |
Cell Cycle Analysis[1] | Cell Line: | HT-29 and LoVo cells | | Concentration: | 25.7 μM for HT-29; 22.8 μM for LoVo | | Incubation Time: | 24, 48 hours | | Result: | Increased the percentage of G0/G1 phase cells. |
Apoptosis Analysis[1] | Cell Line: | HT-29 and LoVo cells | | Concentration: | 25.7 μM for HT-29; 22.8 μM for LoVo | | Incubation Time: | 24, 48 hours | | Result: | Induced apoptosis in both cell lines. |
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体内研究
(In Vivo) | Nemorosone (50 mg/kg; daily i.p. for 28 days) shows a significant growth-inhibitory effect in pancreatic cancer xenografts[2].
| Animal Model: | Athymic NMRI nu/nu nude mices (6 to 8 week old female), which had 100 mm3MIA-PaCa-2 xenograft tumor[2] | | Dosage: | 50 mg/kg | | Administration: | Daily i.p. injections for 28 days | | Result: | Showed a significant growth-inhibitory effect in pancreatic cancer xenografts[2]. |
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| 结构分类 | - Ketones, Aldehydes, Acids
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| 来源 | - Plants
- Rosaceae
- Rosa multifoloraThunb
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
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