Sanguisorbigenin is a natural antibacterial agent that inhibits methicillin-resistantS. aureus(MRSA)^[1].

The minimal inhibitory concentration values of Sanguisorbigenin against six strains ofS. aureusare in the range of 12.5-50 μg/mL^[1].
The expression ofblaR1,mecAandblaZis significantly inhibited in MRSA in a dose-dependent manner when it is treated with sub-MIC (1.56-6.25 μg/mL) concentrations of Sanguisorbigenin. Sanguisorbigenin remarkably reduces the gene expression ofmecA. Sanguisorbigenin has a potent antibacterial effect and could effectively reverse the sense of antibiotics by inhibiting themecAexpression and decrease PBP2a expression^[1].

454.68

Solid

C₃₀H₄₆O₃

6812-98-2

地榆皂苷元

• Terpenoids
• Triterpenes

• Plants
• Rosaceae
• Sanguisorba officinalisLinn.

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)