(±)-Pantothenic acid ((±)-Pantothenate), a B-vitamin, is an essential vitamin required for the biosynthesis of coenzyme A (CoA) in mammalian cells. Pantothenic acid has protective activity against valproic acid (VPA)-induced neural tube defects (NTD) in CD-1 mice^[1].

(±)-Pantothenic acid (3 × 200 mg/kg; IP, single dosage) blocks VPA-induced decreases in c-Myb and Pim-1 protein expression; reduces the incidence of NTD to 6.8% in VPA-injected CD-1 mice, while incidence of the untreated group is 23.6%^[1].

219.23

C₉H₁₇NO₅

599-54-2

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