Arzoxifene (LY353381) is an orally active selectiveestrogen receptormodulator with a fixed ring structure similar to raloxifene. Arzoxifene has minimal side effects with powerful antiestrogenic effects on breastcancerand endometrium, with equally strong favorable estrogenic effects on bone and lipid profile^[1].

estrogen^[1]

Arzoxifene reduces estrogen receptor expression in endometrial cancer cell lines (ECC-1)^[1].

Arzoxifene inhibits MCF-7 breast cancer xenograft growth in oophorectomized athymic mice. Arzoxifene is reported to prevent body weight increase in oophorectomized rats^[1].

475.60

C₂₈H₂₉NO₄S

182133-25-1

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.