Quinagolide hydrochloride

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本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

94424-50-7

包装与价格：

包装	价格(元)
5mg	电议
10mg	电议
50mg	电议
100mg	电议
200mg	电议
500mg	电议

产品名称

盐酸喹高利特
CV205-502 hydrochloride

产品介绍

Quinagolide hydrochloride (CV205-502 hydrochloride) 是选择性的、具有口服活性的多巴胺D2 受体激动剂。Quinagolide hydrochloride 是催乳素抑制剂。Quinagolide hydrochloride 下调AKT的水平及其磷酸化。Quinagolide hydrochloride 具有抗肿瘤活性，可用于癌症的研究。

生物活性

Quinagolide hydrochloride (CV205-502 hydrochloride) is a selective and orally active dopamineD2 receptoragonist. Quinagolide hydrochloride is an inhibitor ofprolactin. Quinagolide hydrochloride down-regulatesAKTlevels and its phosphorylation. Quinagolide hydrochloride shows antitumor effects, it can be used for the research ofcancer^[1]^[2].

体外研究
(In Vitro)

Quinagolide hydrochloride (100 nM; 48 h) reduces non-ergot dopamine receptor 2 (DRD2) mRNA expression in ectopic lines^[2].
Quinagolide hydrochloride (100 nM; 48 h) inhibits the invasive properties of endometrial mesenchymal stromal cells (E-MSCs)^[2].
Quinagolide hydrochloride (100 nM; 24 h) significantly reduces the endothelial differentiation of E-MSCs^[2].

Western Blot Analysis^[2]

Cell Line:	Eutopic and ectopic E-MSCs
Concentration:	100 nM
Incubation Time:	24 h
Result:	Reduced total AKT levels in ectopic E-MSCs and significantly decreased AKT phosphorylation in both eutopic and ectopic cell lines.

体内研究
(In Vivo)

Quinagolide hydrochloride (0.03-0.6 mg/kg; s.c. once daily for 2 month) effectively inhibits tumor growth in vivo^[1].

Animal Model:	Female Wistar-Furth rats bearing SMtTW tumors^[1]
Dosage:	0.03-0.6 mg/kg
Administration:	Subcutaneous injection; 0.03-0.6 mg/kg once daily for 2 month
Result:	Induced normalization of plasma PRL levels in all animals, reduced the tumor size compared with the control group at a dose of 0.3 mg/kg. Showed maximal inhibitory effects on PRL secretion and tumor growth at a dose of 0.3 mg/kg.

Clinical Trial

分子量

432.02

性状

Solid

Formula

C₂₀H₃₄ClN₃O₃S

CAS 号

94424-50-7

中文名称

盐酸喹高利特

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据

In Vitro:

DMSO : 3.85 mg/mL(8.91 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	2.3147 mL	11.5735 mL	23.1471 mL
5 mM	0.4629 mL	2.3147 mL	4.6294 mL
10 mM	---	---	---

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (sealed storage, away from moisture)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。