Mibefradil dihydrochloride hydrate (Ro 40-5967 dihydrochloride hydrate) is a effectively long-actingcalcium channelantagonist, used as an antihypertensive agent. Mibefradil dihydrochloride hydrate acts via a higher affinity block for low-voltage-activated (T) than for high-voltage-activated (L) calcium channels^[1].

Calcium channel^[1]

Mibefradil inhibits reversibly the T- and L-type currents with IC₅₀values of 2.7 and 18.6 μM, respectively^[2].
Mibefradil (20 μM) reduces the amplitude of excitatory junction potentials (by 37±10 %), slows the rate of repolarisation (by 44±16 %) and causes a significant membrane potential depolarisation (from -83±1 mV to -71±5 mV)^[3].

586.57

C₂₉H₄₂Cl₂FN₃O₄

1049728-52-0

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