Chlorpheniramine

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Chlorpheniramine

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

132-22-9

包装与价格：

产品名称

Chlorphenamine

产品介绍

Chlorpheniramine是过敏性疾病常用的H1型抗组胺药.
.
。

生物活性

Chlorpheniramine is aH1 antihistaminescommonly used in allergic diseases^[1].
^[2].
.

IC₅₀& Target

IC50: 43μM in BV2 microglial cells

体外研究
(In Vitro)

Chlorpheniramine has an inhibitory effects with an value ofIC₅₀is 43μM on proton currents in BV2 microglial cells^[1].
.

Cell Viability Assay

Cell Line:	Murine microglial BV2 cells^[1].
Concentration:	100 μM
Incubation Time:	5 min
Result:	Inhibited proton currents with moderate potency.

体内研究
(In Vivo)

Chloropheniramine (50, 100 and 200 μg/kg; IM; 3 times, at intervals of 1 week) enhances white blood cells in the peripheral blood^[2].
.

Animal Model:	Sprague-Dawley (SD) rats^[2].
Dosage:	50, 100 and 200 μg/kg
Administration:	Chlorpheniramine (50, 100 and 200 μg/kg; IM; 3 times, at intervals of 1 week)
Result:	Enhanced white blood cells in the peripheral blood, mostly due to the increases of B cells and monocytes, but not T cells and NK cells.

Clinical Trial

分子量

274.79

Formula

C₁₆H₁₉ClN₂

CAS 号

132-22-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.