NAS-181

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NAS-181

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

205242-62-2

包装与价格：

包装	价格(元)
5mg	电议
10mg	电议
25mg	电议
50mg	电议

产品介绍

NAS-181 是一种有效的选择性大鼠 5-羟色胺 1B (r5-HT1B) 拮抗剂，K_i值为 47 nM。NAS-181 增加大鼠脑区 5-HTP 的积累。

生物活性

NAS-181 is a potent and selectiverat 5-hydroxytryptamine1B (r5-HT1B)antagonist with anK_ivalue of 47 nM. NAS-181 increases the 5-HTP accumulation in rat brain regions^[1].

体外研究
(In Vitro)

NAS-181 (compound (R)-25) (0-1000 nM) increases the K+-stimulated release of [3H]-5-HT from rat occipital cortical slices^[1].
NAS-181 (3 mg/kg; s.c.) increases in the number of wet dog shakes in rats, and the effect is abolished by pretreatment of the rats with the tryptophan hydroxylase inhibitor p-chlorophenylalanine (pCPA) (200 mg/kg; i.p.)^[1].

体内研究
(In Vivo)

NAS-181 (20 mg/kg; s.c.) increases the 5-HTP accumulation in rat brain regions^[1].

Animal Model:	Rats^[1]
Dosage:	20 mg/kg
Administration:	S.c.
Result:	Significantly increased the 5-HTP accumulation in hypothalamus, hippocampus, frontal cortex, striatum, and the ratio 5-HIAA/5-HT in these brain regions was even more elevated (40–60%).

分子量

442.53

Formula

C₂₀H₃₀N₂O₇S

CAS 号

205242-62-2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.