LP 12 hydrochloride hydrate is a potent and selective5-HT7 receptoragonist with aK_iof 0.13 nM. LP 12 hydrochloride hydrate displays selectivity for 5-HT7 over D2, 5-HT1A and 5-HT2A receptors (K_ivalues are 224 nM, 60.9 nM and >1000 nM, respectively)^[1][2].

LP 12 hydrochloride hydrate (0.13 nM; spermatozoa) increases the percentage of hyperactivated spermatozoa. LP 12 hydrochloride hydrate do not affect straight-line velocity (VSL), curvilinear velocity (VCL), average-path velocity (VAP), linearity (LIN), straightness (STR), wobbler coefficient (WOB), amplitude of lateral head displacement (ALH), and beat-cross frequency (BCF)^[2].

Solid

C₃₂H₃₉N₃O.HCl.xH₂O

Room temperature in continental US; may vary elsewhere.