HL271 (IM156 hydrochloride; HL156A hydrochloride), a chemical derivative of Metformin (HY-B0627), is a potentAMPKactivator that increasesAMPKphosphorylation. HL271 attenuates aging-associated cognitive impairment in animal model^[1][2]. HL271 is a potentoxidative phosphorylation (OXPHOS)inhibitor which can be used for the research of solid tumors^[3].

AMPK^[1][2], OXPHOS^[3]

HL271 (0.31-10 μM) phosphorylates AMPKα1 Thr172 in a dose- and time-dependent manner in NIH3T3 mouse fibroblast cells^[1].
HL271 does not affect the expression of key factors involved in glucose homeostasis such as glucose-6-phosphatase (G6pase) or phosphoenolpyruvate carboxykinase 1 (Pck1)^[1].

HL271 does not affect metabolic regulation assessed by body weight, blood glucose, insulin levels and lipid metabolite content in mice with diet-induced obesity^[1].
HL271 (50 mg/kg; for 2 months) does not affect body weight, general locomotion, or anxiety^[2].
HL271 significantly attenuates the aging-induced decline in novel object recognition memory and spatial working memory^[2].
HL271 significantly increases AMPK activation in the hippocampus of aged mice^[2].

351.76

C₁₃H₁₇ClF₃N₅O

1422365-52-3

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