CHMFL-ABL-121 is a highly potent type IIABLkinaseinhibitor withIC₅₀s of 2 nM and 0.2 nM against purified inactiveABLwt and T315I kinase protein, respectively^[1].

CHMFL-ABL-121 dose-dependently inhibits BCRABL's auto-phosphorylation at Y245 site in K562 (EC₅₀<10 nm), meg-01 (ec₅₀<10 nm) and ku812 (ec₅₀<30 nm) cells and also significantly blocks the phosphorylation of downstream signaling mediators stat5, crkl erk^[1].
CHMFL-ABL-121 induces apoptosis and arrests cell cycle at G0/G1 phase^[1].

580.67

C₃₀H₃₁F₃N₆OS

2270879-07-5

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.