Anticancer agent 56 (compound 4d) is a potent anti-cancer agent with drug-likeness properties, possessing anticancer activity against severalcancercell lines (IC₅₀<3 μm). anticancer agent 56 induces cell cycle arrest at g2m phase and triggers mitochondrialapoptosispathway. Anticancer agent 56 acts by accumulation ofROS, up regulation ofBAX, down regulation ofBcl-2and activation ofcaspases 3, 7, 9^[1].

IC₅₀: 0.64 ± 0.02 μM in Leukemia RPMI-8226, 0.96 ± 0.04 μM in Leukemia SR, 0.84 ± 0.07 μM in Leukemia K-562, 0.69 ± 0.01 μM in Melanoma M14, 0.24 ± 0.01 μM in Breast MCF7, 0.26 ± 0.01 μM in Colon HCT116, 2.95 ± 0.14 μM in Prostate PC3^[1]

383.83

C₂₀H₁₈ClN₃O₃

2241915-59-1

Room temperature in continental US; may vary elsewhere.

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