Anti-inflammatory agent 17

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CAS NO:

2763226-84-0

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

Anti-inflammatory agent 17 是一种有效的具有口服活性的消炎药。Anti-inflammatory agent 17 在体外实验中抑制 IL-6 和 TNF-α 的释放且无细胞毒性。Anti-inflammatory agent 17 在体内显示出抗炎活性。Anti-inflammatory agent 17 具有研究急性肺损伤 (ALI) 的潜力。

生物活性

Anti-inflammatory agent 17 is a potent and orally active anti-inflammatory agent. Anti-inflammatory agent 17 inhibits the release ofIL-6and TNF-α in vitro experiments without cytotoxicity. Anti-inflammatory agent 17 exhibits anti-inflammatory activity in vivo. Anti-inflammatory agent 17 has the potential for the research of Acute lung injury (ALI)^[1].

IC₅₀& Target

IL-6

8.254 μM (IC₅₀)

体外研究
(In Vitro)

Anti-inflammatory agent 17 (compound 5b) (10 μM; 24 h) displays no toxicity in J774a.1 cells^[1].
Anti-inflammatory agent 17 (1.25, 2.5, 5, 10 μM; 2 h) inhibits the production of IL-6 (IC₅₀=8.254 μM) and TNF-α (IC₅₀=2.576 μM) in J774a.1 cells in a dose-dependent manner^[1].

Cell Viability Assay^[1]

Cell Line:	J774a.1 cells
Concentration:	10 μM
Incubation Time:	24 h
Result:	Displayed no toxicity in J774a.1 cells.

Immunofluorescence^[1]

Cell Line:	J774A.1 cells
Concentration:	1.25, 2.5, 5, 10 μM
Incubation Time:	2 h
Result:	Inhibited the production of IL-6 (IC₅₀=8.254 μM) and TNF-α (IC₅₀=2.576 μM) in J774a.1 cells in a dose-dependent manner.

体内研究
(In Vivo)

Anti-inflammatory agent 17 (20 mg/kg; intragastric administration) exhibits protective effect on LPS (lipopolysaccharide)-induced ALI in mice^[1].

Animal Model:	C57/BL6 mice^[1]
Dosage:	20 mg/kg
Administration:	Intragastric administration
Result:	Exhibited protective effect on LPS-induced ALI in mice.

分子量

357.40

Formula

C₂₀H₂₃NO₅

CAS 号

2763226-84-0

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.