SB 706504 is a potentp38 MAPKinhibitor that inhibitsLipopolysaccharides(HY-D1056)-stimulated inflammatory gene expression in macrophages in chronic obstructive pulmonary disease (COPD)^[1].

SB 706504 (3 μM, 6 h)可显着降低 IL-1β、IL-6、GM-CSF、TNFα 和 IL-8 mRNA 水平，在 LPS 刺激的 单核细胞来源的巨噬细胞 （MDM）中^[1]。
SB 706504(3 μM, 6 h)可显着降低 COPD 患者肺泡巨噬细胞（AM）中 LPS 诱导的 TNFα 水平，抑制率为 67.4%^[1]。

492.46

C₂₄H₁₉F₃N₈O

911110-38-8

Room temperature in continental US; may vary elsewhere.

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