Neocryptotanshinone

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Neocryptotanshinone

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

109664-02-0

包装与价格：

包装	价格(元)
5mg	电议
10mg	电议
50mg	电议
100mg	电议

产品名称

新隐丹参酮

产品介绍

Neocryptotanshinone 是从丹参 (Salvia Miltiorrhiza) 分离得到的一种丹参二萜，通过抑制NF-κB和iNOS信号来抑制脂多糖 (LPS) 诱导的炎症。

生物活性

Neocryptotanshinone, a fattyditerpenoidsfromSalvia Miltiorrhiza, inhibits lipopolysaccharide-induced inflammation by suppression ofNF-κBandiNOSsignaling pathways^[1]^[2].

IC₅₀& Target

Target: NF-κB, iNOS^[1]

体外研究
(In Vitro)

Neocryptotanshinone exhibits anti-inflammatory effect by suppression of NF-κB and iNOS signaling pathways^[1].
Neocryptotanshinone (10 μM and 20 μM, 24 h) inhibits LPS-induced iNOS protein expression in RAW264.7 cells^[1].
Neocryptotanshinone (20 μM, 24 h) shows no obvious cytotoxic effect towards murine RAW264.7 macrophages^[1].

Cell Viability Assay^[1]

Cell Line:	RAW264.7 cells
Concentration:	5, 10 and 20 μM
Incubation Time:	24 hours
Result:	Inhibited LPS-induced cell viability in a dose-dependent manner.

Western Blot Analysis^[1]

Cell Line:	RAW264.7 cells
Concentration:	20 μM
Incubation Time:	24 hours
Result:	Inhibited LPS-induced activation of NF-κB pathway and down-regulated LPS-induced expression of p-NF-κB p65, p-IκBα and p-IKKβ.

体内研究
(In Vivo)

Neocryptotanshinone causes reversals of decreased pain thresholds induced by MSU treatment after 30, 60, and 120 min S. miltiorrhiza Bunge extract treatment (contains single active components)^[3].

Animal Model:	MSU-induced pain model in male ICR mice (weighing 20-25 g)^[2]
Dosage:	10, 25, 50 or 100 mg/kg
Administration:	Oral gavage; for 30, 60, 120 min
Result:	Inhibited inflammatory symptoms and nociceptive behaviors in a dose-dependent manner.

分子量

314.38

性状

Solid

Formula

C₁₉H₂₂O₄

CAS 号

109664-02-0

中文名称

新隐丹参酮

结构分类

Terpenoids
Diterpenoids

Quinones
Naphthalene Quinones

来源

Plants
Compositae
Hemistepta lyrata

Plants
Labiatae

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据

In Vitro:

DMSO : 100 mg/mL(318.09 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	3.1809 mL	15.9043 mL	31.8086 mL
5 mM	0.6362 mL	3.1809 mL	6.3617 mL
10 mM	0.3181 mL	1.5904 mL	3.1809 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month (protect from light)。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。