Helenalin

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Helenalin

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

6754-13-8

包装与价格：

包装	价格(元)
500 μg	电议
1mg	电议
5mg	电议
10mg	电议

产品介绍

Helenalin 是一种抗炎的倍半萜内酯。Helenalin 通过直接靶向 p65 选择性抑制转录因子NF-κB。Helenalin 具有烷基化活性，以 NF-κB 的 p65 亚基中的半胱氨酸巯基为靶点，从而抑制其 DNA 结合。

生物活性

Helenalin is an anti-inflammatory sesquiterpene lactone. Helenalin selectively inhibits transcription factorNF-κBby directly targeting p65. Helenalin has alkylating activity, targets the cysteine sulfhydryl groups in the p65 subunit ofNF-κB, thereby inhibits its DNA binding^[1]^[2].

体外研究
(In Vitro)

Helenalin (10 μM; 20-120 minutes) causes complete inhibition of NF-κB DNA binding after 80 minutes^[1].
The anti-inflammatory, anti-carcinogenic phytochemical, Helenalin is a potent inhibitor of periodic Skp2 accumulation, an F-box protein mediating SCF E3 ligase ubiquitylation and degradation of both CKIs during S phase progression^[3].

Western Blot Analysis^[1]

Cell Line:	Jurkat T cells
Concentration:	10 μM
Incubation Time:	20-120 minutes
Result:	Caused complete inhibition of NF-κB DNA binding after 80 minutes.

体内研究
(In Vivo)

Helenalin (25 mg/kg; i.p.; 6 to 12 hours) administers to immature male ICR mice caused a rapid decrease in hepatic glutathione levels^[2].

Animal Model:	Immature male ICR mice^[2]
Dosage:	25 mg/kg
Administration:	i.p.; 6 to 12 hours
Result:	Caused a rapid decrease in hepatic glutathione levels.

分子量

262.30

性状

Solid

Formula

C₁₅H₁₈O₄

CAS 号

6754-13-8

结构分类

Terpenoids
Sesquiterpenes

来源

Plants
other families

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : 100 mg/mL(381.24 mM;Need ultrasonic)

配制储备液

浓度溶剂体积质量

1 mg

5 mg

10 mg

1 mM	3.8124 mL	19.0621 mL	38.1243 mL
5 mM	0.7625 mL	3.8124 mL	7.6249 mL
10 mM	0.3812 mL	1.9062 mL	3.8124 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。