NF023 hexasodium is a selective and competitiveP2X₁receptorantagonist, withIC₅₀values of 0.21 μM, 28.9 μM, >50 μM and >100 μM for human P2X₁, P2X₃, P2X₂, and P2X₄-mediated responses respectively^[1][2][3][4].

NF023 is selective for recombinant Gi alpha-1 and recombinant Go alpha (EC₅₀value of approximately 300 nM)^[2].
NF023 inhibits P2X1 receptors in a voltage-insensitive manner. NF023 (5 and 30 μM) causes a shift of the concentration-response curve to the right without affecting the maximal response to ATP (K_B=1.190.2 μM)^[4].

NF023 (100 μmol/kg i.v.) antagonizes vasopressor responses to α,β-mATP but not to noradrenaline In pithed rats^[3].

1162.88

Solid

C₃₅H₂₀N₄Na₆O₂₁S₆

104869-31-0

Room temperature in continental US; may vary elsewhere.

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)