Artemisitene, a natural derivative of Artemisinin, is aNrf2activator with antioxidant and anticancer activities. Artemisitene activates Nrf2 by decreasing Nrf2 ubiquitination and increasing its stability^[1][2].

Artemisitene selectively induces DNA double-stranded breaks (DSBs) and apoptosis in various human cancer cells by suppressing the expression of topoisomerases in human cancer cells. Artemisitene selectively destabilizes c-Myc in human cancer cells by promoting the ubiquitination of c-Myc through the specific induction of the c-Myc E3 ligase NEDD4^[2].

In Nrf2 wild-type mice, systemic administration of Artemisitene (5-10 mg/kg; i.p.) strongly inhibits bleomycin-induced lung damage^[1].

280.32

Solid

C₁₅H₂₀O₅

101020-89-7

青蒿烯

• Terpenoids
• Sesquiterpenes

• Plants
• Leguminosae
• Piscidia erythrinaL.

• Plants
• Compositae

Room temperature in continental US; may vary elsewhere.

DMSO : ≥ 100 mg/mL(356.74 mM)

*"≥" means soluble, but saturation unknown.

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储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。