Nizofenone

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Nizofenone

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

54533-85-6

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品名称

尼唑苯酮；硝唑芬酮；米唑硝苯酮

产品介绍

Nizofenone 是一种神经保护剂，可在脑缺血或缺氧后保护神经元免于死亡。Nizofenone 可用于研究急性神经系统疾病，例如中风。

生物活性

Nizofenone is a neuroprotective agent which protects neurons from death following cerebral ischemia or anoxia. Nizofenone can be used in the research of acute neurological conditions, such as stroke^[1]^[2]^[3].

体外研究
(In Vitro)

Nizofenone (1 and 10 μM) prolongs the action potential duration of guinea-pig papillary muscle and dog Purkinje fibers^[3].
Nizofenone (30 μM) suppresses the spontaneous activity of dog Purkinje fibers and guinea-pigs S-A node^[3].
Nizofenone (100 μM) decreases the contractile force of guinea-pig papillary muscle^[3].
Nizofenone (10 μM) inhibits the peroxidative disintegration of mitochondria (in rat brain mitochondrial suspension)^[4].

体内研究
(In Vivo)

Nizofenone (3 and 9 mg/kg, i.p., daily) attenuates the chronic restraint stress (CRS)-induced cognitive impairments^[1].
Nizofenone (10 mg/kg i.p.) inhibits ischemia-induced glutamate increase and lactate increase in the hippocampus of rats^[2].

Animal Model:	Mice with chronic restraint stress^[1]
Dosage:	3, 9 mg/kg
Administration:	Intraperitoneal injection (i.p.), daily
Result:	Increased crossing frequencies of the open field test. Increased in the activities of enzymatic SOD and CAT.

分子量

412.87

Formula

C₂₁H₂₁ClN₄O₃

CAS 号

54533-85-6

中文名称

尼唑苯酮；硝唑芬酮；米唑硝苯酮

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.