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Tenidap
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Tenidap图片
CAS NO:120210-48-2
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
Tenidap 是一种非甾体抗炎药，是一种选择性 COX-1 抑制剂，对 COX-1 和 COX-2 的 IC50 值分别为 0.03 μM 和 1.2 μM。
Cas No.120210-48-2
别名替尼达普,CP-66248
化学名(E)-5-chloro-3-(hydroxy(thiophen-2-yl)methylene)-2-oxoindoline-1-carboxamide
Canonical SMILESClC1=CC=C(C(/C2=C(C3=CC=CS3)\O)=C1)N(C(N)=O)C2=O
分子式C14H9N2O3SCl
分子量320.75
溶解度DMF: 10 mg/ml,DMSO: 20 mg/ml,Ethanol: slightly soluble
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Tenidap, a non-steroidal anti-inflammatory drug, is a selective COX-1 inhibitor, with IC50 values of 0.03 μM and 1.2 μM for COX-1 and COX-2, respectively. Tenidap has anti-inflammatory and antirheumatic properties[1][2]. Tenidap is also a specific SLC26A3 inhibitor.

References:
[1]. Kirchner T, et al. Evaluation of the antiinflammatory activity of a dual cyclooxygenase-2 selective/5-lipoxygenase inhibitor, RWJ 63556, in a canine model of inflammation. J Pharmacol Exp Ther. 1997 Aug;282(2):1094-101.
[2]. Blackburn WD Jr, et al. Tenidap in rheumatoid arthritis. A 24-week double-blind comparison with hydroxychloroquine-plus-piroxicam, and piroxicam alone. Arthritis Rheum. 1995 Oct;38(10):1447-56.