Delphinidin-3-sambubioside (Dp3-Sam) chloride 一种具有口服活性的花青素，具有抗炎活性。Delphinidin-3-sambubioside chloride 抑制 LPS 诱导的炎症因子释放。Delphinidin-3-sambubioside chloride 还可以减轻 HFD 大鼠的肝脏脂质积累。Delphinidin-3-sambubioside chloride 可以从Hibiscus sabdariffa L.中分离出来。
| 生物活性 | Delphinidin-3-sambubioside (Dp3‐Sam) chloride is an anthocyanin that has orally active anti-inflammatory activity. Delphinidin-3-sambubioside chloride inhibits LPS-induced inflammatory factors release. Delphinidin-3-sambubioside chloride also alleviates hepatic lipid accumulation in HFD rats. Delphinidin-3-sambubioside chloride can be isolated fromHibiscus sabdariffa L.[1][3]. |
体外研究
(In Vitro) | Delphinidin-3-sambubioside chloride (50-200 μM, 30 min) inhibits LPS-induced iNOS expression in RAW264.7 cells[1].
Delphinidin-3-sambubioside chloride (50-200 μM, 30 min) suppresses the phosphorylation of ERK1/2 and MEK1/2 in RAW264.7 cells[1].
Delphinidin-3-sambubioside chloride (50-200 μM, 30 min) downregulates NF-κB signaling pathway in RAW264.7 cells[1].
Delphinidin-3-sambubioside chloride (24 h) inhibits HL-60 cells proliferation by inducing apoptosis, with an IC50of 75 μM[2].
Delphinidin-3-sambubioside chloride (100-200 μg/mL, 24 h) decreases intracellular TG levels and lipid accumulation in oleic acid-treated HepG2 cells[2].
Western Blot Analysis[1] | Cell Line: | RAW264.7 cells | | Concentration: | 50, 100, 200 μM | | Incubation Time: | 30 min | | Result: | Suppressed the degradation of IκB, and the phosphorylation of p65. |
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体内研究
(In Vivo) | Delphinidin-3-sambubioside chloride (15 μmol/kg, i.p.) inhibits mouse paw edema induced by LPS[1].
Delphinidin-3-sambubioside chloride (30 mg/kg body, oral gavage, daily for eight weeks) decreases lipid accumulation in HFD rats[3].
| Animal Model: | Delphinidin-3-sambubioside chloride (15 μmol/kg, i.p.) 抑制 LPS 诱导的小鼠爪水肿[1].
Delphinidin-3-sambubioside chloride (30 mg/kg body，灌胃，每日一次，持续八周) 减少 HFD 大鼠的脂质积累[3]。
| | Dosage: | 15 μmol/kg | | Administration: | Intraperitoneal injection (i.p.), for 4 days. | | Result: | Reduced the LPS-induced paw thickness.
Decreased the edema by 89.3%.
Decreased the levels of LPS induced serum IL-6, MCP-1 and TNF-α. |
| Animal Model: | HFD-fed rats[3] | | Dosage: | 30 mg/kg | | Administration: | Oral gavage, daily for eight weeks. | | Result: | Reduced the body weight gain, visceral fat, and abdominal fat and decreased hepatic lipid deposits. |
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| 分子量 | |
| Formula | |
| CAS 号 | |
| 结构分类 | - Flavonoids
- Other Flavonoids
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| 来源 | - Plants
- Malvaceae
- Hibiscus sabdariffaLinn.
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| 运输条件 | Room temperature in continental US; may vary elsewhere. |
| 储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |
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