Tricetin is a potent competitive inhibitor of theKeap1-Nrf2Protein Protein Interaction (PPI). Tricetin protects against 6-OHDA-induced neurotoxicity in Parkinson's disease model by activating Nrf2/HO-1 signaling pathway and preventing mitochondria-dependentapoptosispathway^[1].

Tricetin is mainly found in natural plants such as Ginkgo biloba L., Carica papaya L. and Murraya exotica L. Tricetin activates the Nrf2/HO-1 pathway to protect cells from oxidative stress. Tricetin possessed the protective effect on dopamine neurons of C. elegans. Tricetin has cytostatic properties and anti-metastatic activity of various solid tumors^[1].
Pretreatment with Tricetin (20, 40, and 80 μM; for 4 hours) significantly improves 6-OHDA (200 μM)-induced SH-SY5Y cells viability and suppresses mitochondria-mediated apoptosis^[1].
Tricetin (80 μM; for 1, 2 and 4 h) markedly decreased the expressions of p-JNK and p-p38^[1].

302.24

Solid

C₁₅H₁₀O₇

520-31-0

三粒小麦黄酮

• Flavonoids
• Flavonols

• Plants
• Cupressaceae
• Thuja occidentalisLinn.

Room temperature in continental US; may vary elsewhere.