| CAS NO: | 339-72-0 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 25mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| 250mg | 电议 |
| 500mg | 电议 |
| 1g | 电议 |
| Molecular Weight (MW) | 102.09 |
|---|---|
| Formula | C3H6N2O2 |
| CAS No. | 339-72-0 |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 8 mg/mL (78.4 mM) |
| Water: 20 mg/mL (196 mM) | |
| Ethanol: | |
| Solubility (In vivo) | |
| Synonyms | (-)-Cycloserine, (S)-Cycloserine, Levcycloserine, Levcicloserina, Levcycloserinum |
| SMILES Code | O=C1NOC[C@@H]1N |
| In Vitro | In vitro activity: L-Cycloserine is an inhibitor of the 3-ketodihydrosphin-gosine (3KDS) synthase (serine palmitoyltransferase) which is 1st enzyme of the sphingolipid pathway, it causes an irreversible inhibition of 3KDS synthase derived from a bacterial source (Bacteroides levii) and from brain and heart microsomes in vitro. Kinase Assay: Cell Assay: |
|---|---|
| In Vivo | Long-term and subcutaneous administration of a low dose of L-cycloserine to mice significantly reduces the level of brain cerebrosides with little effect on other sphingolipids |
| Animal model | New Zealand White rabbits |
| Formulation & Dosage | Formulated in PBS (pH7.2); 10 or 25 mg/kg; i.p. |
| References | Neurochem Res. 1989 Mar;14(3):245-8. |
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