Belizatinib is an oral, dual, potent inhibitor of ALK andTRKA,TRKB, andTRKC, withIC₅₀of 0.7 nM for wild-type recombinant ALK kinase.

IC50: 0.7 nM (ALK)^[1]

TSR-011 has antitumour activity in the clinical trials.

TSR-011 exerts sustained potent inhibition of ALK-dependent tumour growth in mouse models^[1].

577.73

Solid

C₃₃H₄₄FN₅O₃

1357920-84-3

Room temperature in continental US; may vary elsewhere.

DMSO : ≥ 300 mg/mL(519.27 mM)

*"≥" means soluble, but saturation unknown.

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。