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Itanapraced(CHF5074)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Itanapraced(CHF5074)图片
CAS NO:749269-83-8
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议
10mg电议
50mg电议
100mg电议

产品介绍
Itanapraced (CHF5074) (CHF5074) 是一种新型的 γ-分泌酶调节剂，可减少 Aβ42 和 Aβ40 的分泌，IC50 分别为 3.6 和 18.4 μM。
Cas No.749269-83-8
别名CHF5074; CSP-1103
Canonical SMILESOC(C1(CC1)C(C=C2)=CC(F)=C2C3=CC=C(Cl)C(Cl)=C3)=O
分子式C16H11Cl2FO2
分子量325.16
溶解度DMSO : ≥ 37 mg/mL (113.79 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Itanapraced (CHF5074) is a novel γ-secretase modulator, reduces Aβ42 and Aβ40 secretion, with an IC50 of 3.6 and 18.4 μM, respectively.

[1]. Imbimbo BP, et al. 1-(3',4'-Dichloro-2-fluoro[1,1'-biphenyl]-4-yl)-cyclopropanecarboxylic acid (CHF5074), a novel gamma-secretasemodulator, reduces brain beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease withoutcausing peripheral toxicity. J Pharmacol Exp Ther. 2007 Dec;323(3):822-830. [2]. Mango D, et al. Electrophysiological and metabolic effects of CHF5074 in the hippocampus: protection against in vitro ischemia. Pharmacol Res. 2014 Mar;81:83-90.