Compound 48/80 (Poly-p-methoxyphenethylmethylamine) is widely used in animal and tissue models as a "selective"mast cellactivator. Compound 48/80 acts at the mast cell membrane to stimulate trimeric G-proteins and induces degranulation viaphospholipaseC and D pathways^[1][2].

Mast Cell Activator^[1]

Compound 48/80 (poly-p-methoxyphenethylmethylamine), an agent commonly used to trigger degranulation of mast cells, at concentrations of 5-20 μg/ml suppresses the proliferation of L1210 and Friend leukemic cells in vitro, inducing the formation of giant cells, which are polykaryons^[3].

519.72

C₃₂H₄₅N₃O₃

94724-12-6

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.