PACOCF3 (Palmityltrifluoromethylketone) is a selectivephospholipaseA2inhibitor with anIC₅₀of 3.8 μM. PACOCF3 alters Ca²⁺signaling in renal tubular cells^[1][2].

At a concentration of 20 μM, PACOCF3 does not change basal cytosolic free calcium concentrations ([Ca²⁺]_i), but at concentrations of 50-250 μM PACOCF3 induced an increase in [Ca²⁺]_iby activating extracellular Ca²⁺entry which is partly suppressed by 50 μM La3+^[2].
The effect of PACOCF3 is abolished by removal of extracellular Ca²⁺. PACOCF3 (10 μM) enhances both the peak value and the area under the curve of the [Ca²⁺]_iincrease induced by 10 μM ATP and 1 μM bradykinin by potentiating extracellular Ca²⁺influx without affecting internal Ca²⁺release^[2].

308.42

Solid

C₁₇H₃₁F₃O

141022-99-3

Room temperature in continental US; may vary elsewhere.

DMSO : 33.33 mg/mL(108.07 mM;Need ultrasonic)

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