CTTHWGFTLC,CYCLIC

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CTTHWGFTLC,CYCLIC

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

244082-19-7

包装与价格：

产品介绍

CTTHWGFTLC, CYCLIC 是一种基质金属蛋白酶MMP-2和MMP-9的环肽抑制剂。对 MMP-9 的IC₅₀约为 8 μM。

生物活性

CTTHWGFTLC, CYCLIC is a cyclic peptide inhibitor formatrix metalloproteinasesMMP-2andMMP-9. TheIC₅₀value forMMP-9is ~8 μM^[1].

IC₅₀& Target

MMP-9

MMP-2

体外研究
(In Vitro)

CTTHWGFTLC, CYCLIC inhibits endothelial and tumor cell migration in vitro^[1].

体内研究
(In Vivo)

CTTHWGFTLC, CYCLIC inhibits tumor progression in vivo, in mouse models^[1].

分子量

1166.33

Formula

C₅₂H₇₁N₁₃O₁₄S₂

CAS 号

244082-19-7

Sequence

Cys-Thr-Thr-His-Trp-Gly-Phe-Thr-Leu-Cys (Disulfide Bridge: Cys1-Cys10)

Sequence Shortening

CTTHWGFTLC (Disulfide Bridge: Cys1-Cys10)

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

H₂O

Peptide Solubility and Storage Guidelines:

1. Calculate the length of the peptide.

2. Calculate the overall charge of the entire peptide according to the following table:

	Contents	Assign value
Acidic amino acid	Asp (D), Glu (E), and the C-terminal -COOH.	-1
Basic amino acid	Arg (R), Lys (K), His (H), and the N-terminal -NH₂	+1
Neutral amino acid	Gly (G), Ala (A), Leu (L), Ile (I), Val (V), Cys (C), Met (M), Thr (T), Ser (S), Phe (F), Tyr (Y), Trp (W), Pro (P), Asn (N), Gln (Q)	0

3. Recommended solution:

Overall charge of peptide	Details
Negative (<0)	1. Try to dissolve the peptide in water first. 2. If water fails, add NH₄OH (<50 μL). 3. If the peptide still does not dissolve, add DMSO (50-100 μL) to solubilize the peptide.
Positive (>0)	1. Try to dissolve the peptide in water first. 2. If water fails, try dissolving the peptide in a 10%-30% acetic acid solution. 3. If the peptide still does not dissolve, try dissolving the peptide in a small amount of DMSO.
Zero (=0)	1. Try to dissolve the peptide in organic solvent (acetonitrile, methanol, etc.) first. 2. For very hydrophobic peptides, try dissolving the peptide in a small amount of DMSO, and then dilute the solution with water to the desired concentration.