Mersalyl

立即咨询

Mersalyl

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

492-18-2

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品名称

Salirgan
Salurin
Salyrgan

产品介绍

Mersalyl (Salirgan) 是一种有效的血管内皮生长因子 (VEGF) 和缺氧诱导因子 1 (HIF-1) 诱导剂。Mersalyl 诱导 VEGF 和 ENO1 mRNA 表达。Mersalyl 具有利尿作用。

生物活性

Mersalyl (Salirgan) is a potentvascular endothelial growth factor (VEGF)andhypoxia-inducible factor 1 (HIF-1)inducer. Mersalyl inducesVEGFand ENO1 mRNA expression. Mersalyl shows diuresis effects^[1]^[2]^[3].

体外研究
(In Vitro)

Mersalyl (100 μM) induces VEGF and ENO1 mRNA expression but inhibits EPO mRNA expression induced by hypoxia, DFO, or CoCl2^[2].
Mersalyl (20 μM; 5 min) is a cell-impermeant organomercurial compound that reacts with free thiol groups in mitochondrial membrane protein^[1].

RT-PCR^[2]

Cell Line:	Hep3B cells
Concentration:	100 μM
Incubation Time:	6 h
Result:	Induced VEGF and ENO1 mRNA expression but inhibited EPO mRNA expression induced by hypoxia, DFO, or CoCl2.

体内研究
(In Vivo)

Mersalyl (2.5-40 mg/kg; intramuscularly injection) shows diuresis effects in Rats^[3].

Animal Model:	Rats^[3]
Dosage:	2.5-40 mg/kg
Administration:	Intramuscularly injection
Result:	Significantly depressed in sulfhydryl concentration at 5 mg/kg.

分子量

505.85

Formula

C₁₃H₁₆HgNNaO₆

CAS 号

492-18-2

中文名称

汞撒利

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.