ML198 is aglucocerebrosidase(GCase) modulator with anEC₅₀of 0.4 μM. ML198 is an activator and non-inhibitory chaperone of glucocerebrosidase. ML198 can be used for the research of Gaucher disease^[1].

EC₅₀: 0.4 μM (glucocerebrosidase)^[1]

ML198 is stable in D-PBS pH 7.4 at room temperature over 48 hr^[1].
ML198 increases translocation of GCase to the lysosome (20% cell translocation at 5 μM, compared to 5% of DMSO) in human fibroblasts^[1].
ML198 shows promising microsomal stability and Caco-2 permeability, with low water solubility^[1].

290.32

Solid

C₁₇H₁₄N₄O

1380716-06-2

Room temperature in continental US; may vary elsewhere.

DMSO : 5 mg/mL(17.22 mM;ultrasonic and warming and adjust pH to 2 with HCl and heat to 60℃)

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储备液的保存方式和期限：-80℃, 6 months; -20℃, 1 month。-80℃ 储存时，请在 6 个月内使用，-20℃ 储存时，请在 1 个月内使用。