RA-2 is a negative-gating modulator ofKCa2/3 channelswith anIC₅₀of 17 nM. RA-2 inhibits bradykinin-induced endothelium-derived hyperpolarization (EDH)-type relaxation in U46619-precontracted rings. RA-2 can help to define the physiologic and pathomechanistic roles of KCa2/3 in the vasculature, central nervous system, and during inflammation^[1].

414.36

C₂₂H₁₆F₂O₆

1867107-62-7

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