Mutabilol

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Mutabilol

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

Mutabilol (compound 1) 是一种有效的 p-糖蛋白 (P-gp) 调节剂。Mutabilol 是一种可以从Plectranthus mutabilis叶中分离得到的天然产物。Mutabilol 增加 NCI-H460/R 细胞中P-gp 的表达。

生物活性

Mutabilol (compound 1) is a potentp-glycoprotein(P-gp)regulator. Mutabilol is a nature product could be isolated fromPlectranthus mutabilisleaves. Mutabilol increases the P-gp expression in NCI-H460/R cells^[1].

体外研究
(In Vitro)

Mutabilol (compound 1; 2, 5, 10, 20, and 50 μM; 72 h) has low toxicity with IC₅₀values of >50, >50, and >50 μM for NCI-H460, NCI-H460/R, and MRC-5 cells, respectively^[1].
Mutabilol (5 and 10 μM; 72 h) stimulates P-gp activity by a direct interaction and decreases the Rho123 accumulation in NCI-H460/R cells^[1].

Cell Viability Assay^[1]

Cell Line:	NCI-H460, NCI-H460/R, and MRC-5 cells
Concentration:	2, 5, 10, 20, and 50 μM
Incubation Time:	72 hours
Result:	Showed low toxicity of cancer cell lines (IC₅₀>50μM)

分子量

332.39

Formula

C₁₉H₂₄O₅

结构分类

Terpenoids
Diterpenoids

来源

Plants
Labiatae
Plectranthus mutabilisCodd

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.