SR-717 free acid is a non-nucleotideSTINGagonist withEC₅₀s of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively. SR-717 free acid is a stable cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) mimetic. Antitumor activity^[1].

SR-717 activates STING by inducing the same closed conformation, which thereby provides an avenue to explore this class of systemic STING agonist in diverse contexts, including antitumor immunity^[1].
SR-717 (3.8 μM) induces the expression of PD-L1 in THP1 cells and in primary human peripheral blood mononuclear cells in a STING-dependent manner^[1].

SR-717 (30 mg/kg intraperitoneal once-per-day for 1 week) shows antitumor activities in WT orSting^gt/gtmice^[1].
SR-717 (30 mg/kg intraperitoneally for 7 days) displays antitumor activity; promots the activation of CD8⁺T, natural killer, and dendritic cells in relevant tissues; and facilitates antigen cross-priming^[1].

345.26

C₁₅H₉F₂N₅O₃

2375420-34-9

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.