cGAMP (Cyclic GMP-AMPP) functions as an endogenous second messenger in metazoans and triggers interferon production in response to cytosolic DNA. cGAMP activates stimulator of interferon genes (STING), which activates a signaling cascade leading to the production of type I interferons and other immune mediators^[1][2][3][4].

Endogenous Metabolite

cGAMP promotes the antigen-specific proliferation capacity of spleen cells in mice^[2].
cGAMP directly activates murine and human dendritic cells in vitro^[2].
On stimulation with cGAMP, fibroblasts from the patients showed increased transcription of IFNB1 but not of the genes encoding interleukin-1 (IL1), interleukin-6 (IL6), or tumor necrosis factor (TNF)^[3].
cGAMP activates the endoplasmic reticulum (ER)-resident receptor STING, thereby inducing an antiviral state and the secretion of type I IFNs^[4].

cGAMP promotes the antigen-specific cytokine production by spleen cells of immunized mice^[2].

674.41

Solid

C₂₀H₂₄N₁₀O₁₃P₂

849214-04-6

Room temperature in continental US; may vary elsewhere.

H₂O : 20 mg/mL(29.66 mM;Need ultrasonic)

DMSO :< 1 mg/mL (ultrasonic)(insoluble or slightly soluble)

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