6H05 is a selective, and allosteric inhibitor of oncogenic mutant K-Ras(G12C). IC50 value: Target:K-RasG12C 6H05 gives the greatest degree of modification, which allosterically modifies the oncogenic G12C mutant of highly homologous proteinH-Raswithout affecting wild-typeK-Ras[1]. 6H05 can be used as an intermediate for the synthesis of other oncogenic K-Ras(G12C) inhibitors [2].

476.12

C₂₀H₃₀ClN₃O₂S₃

1469338-01-9

Room temperature in continental US; may vary elsewhere.

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